Gyne Lotrimin

Combipatch Medication - Uses & Side Effects

CombiPatch™ skin patches are a mixture of a natural estrogen female hormone and a progestin. It is essential for maintaining normal female functions and is normally produced by the ovaries. Because after menopause, the ovaries decrease their production of this hormone. It is used to treats symptoms of the menopause such as hot flashes, night sweats, mood changes, and vaginal dryness and irritation.

Combipatch Dosage

  • The usual starting dose is one patch containing 0.05 milligrams estradiol and 0.14 milligrams norethindrone acetate and you should be applied twice a week.
  • If you are using estradiol-only patch, then you should be applied twice a week for the first 14 days of a 28-day cycle.

Uses of Combipatch

  • Together, estradiol and norethindrone are used to treat the symptoms of menopause such as feelings of warmth in the face, neck and chest, or sudden intense spells of heat and sweating to treat vulvar and vaginal changes caused by menopause.
  • It may also be used to treats other medical conditions those are listed in this medication guide.

Side Effects of Combipatch

Before taken Combipatch medicine, you should discuss the side effects with your doctor. If any develop or change in intensity, then you should inform your doctor as soon as possible. Because only your doctor can determine if it is safe for you to continue taking Combipatch. Side effects may include:

  • Abdominal pain
  • Back pain
  • Dizziness
  • Flu symptoms
  • Headaches
  • Menstrual problems
  • Nausea
  • Painful menstruation
  • Respiratory problems
  • Skin reaction
  • Vaginal inflammation

Warnings and precautions before taking Combipatch:

  • You should be used estrogen with extra caution if you have severely low blood levels of calcium.
  • Hormone therapy may also causes a rise in blood pressure. If you have a blood pressure problem, then you should be used CombiPatch with extra caution.
  • Hormones may also cause fluid retention. So if you have a condition that could be aggravated by excess fluid such as asthma, epilepsy, migraine headaches, heart disease, or kidney problems, then you should be used this drug with caution and also tell your doctor.

Drug Interaction :-If you are taking Combipatch with certain other drugs, then the effects of either could be increased, decreased, or altered. Before using estradiol and norethindrone, you should tell your doctor if you are taking an anticoagulant such as warfarin.


After taken Combipatch if you feel that overdose is suspected, then you should contact with your doctor immediately. Because it may lead to another serious effect. Symptoms of a Combipatch overdose include

  • Nausea
  • Vomiting
  • Withdrawal bleeding may occur in females

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