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Comtan Medication - Uses & Side Effects

Entacapone is an inhibitor of catechol-O-methyltransferase. It is used in combination with levodopa and carbidopa to treat the end-of-dose 'wearing-off' symptoms of Parkinson's disease.

Comtan Dosage

  • The usual starting dose is one 200-milligram tablet with each dose of Sinemet, up to a maximum of 8 doses per day.

Uses of Comtan

  • Comtan is a catechol-o-methyltransferase inhibitor used along with levodopa/carbidopa to treat Parkinson's disease.
  • It may also be used to treats other medical conditions those are listed in this medication guide.

Side Effects of Comtan

Before taken Comtan medicine, you should discuss the side effects with your doctor. If any develop or change in intensity, then you should inform your doctor as soon as possible. Because only your doctor can determine if it is safe for you to continue taking Comtan. Side effects may include:

  • Abdominal pain
  • Back pain
  • Constipation
  • Diarrhea
  • Nausea

Warnings and precautions before taking Comtan:

  • You should tell your doctor if you are allergic to entacapone or any other drugs.
  • You should tell your doctor what prescription and nonprescription medications you are taking, especially ampicillin, apomorphine, bitolterol, chloramphenicol, cholestyramine, medications that cause drowsiness, dobutamine, epinephrine, erythromycin, and vitamins and herbal products.
  • If you have or have ever had liver disease or a history of alcoholism, then you should tell your doctor.
  • You should tell your doctor if you are pregnant, plan to become pregnant.

Drug Interaction :-If you are taking Comtan with certain other drugs, then the effects of either could be increased, decreased, or altered. So it is especially important to check with your doctor before combining Comtan with the following:

  • Antidepressant drugs classified as MAO inhibitors, including Nardil and Parnate
  • Bitolterol
  • Cholestyramine
  • Methyldopa
  • Isoproterenol
  • Probenecid
Overdose

Symptoms of an entacapone overdose are not known. But after taken Comtan if you feel that overdose is suspected, then you should contact with your doctor immediately. Because it may lead to another serious effect.


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